c chemicals Search Results


c chemicals  (Merck & Co)
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Merck & Co c chemicals
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◦ c  (Tokyo Chemical Industry)
86
Tokyo Chemical Industry ◦ c
◦ C, supplied by Tokyo Chemical Industry, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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c176 s6575  (Selleck Chemicals)
94
Selleck Chemicals c176 s6575
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furo 2 3 c pyran 2one  (Toronto Research Chemicals)
88
Toronto Research Chemicals furo 2 3 c pyran 2one
Furo 2 3 C Pyran 2one, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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gabapentin  (Toronto Research Chemicals)
86
Toronto Research Chemicals gabapentin
IS MBP(84-104) causes striking sexual dimorphism in spinal nociceptive signaling. a, neuropathic pain network of PLC/IP3R/VGCC axis and ESR1/p300/CBP axis after IS MBP(84-104) in females (left panel) and males (right panel). Pathway components (molecules and complexes) are displayed as circles, arrows indicate molecular interactions according to Ingenuity IPA (Qiagen). Downstream biological processes are highlighted in blue. Red and green colors correspond to up- and down-regulated DE genes according to the color scale (log2FC). Gradient colors indicate regulation of individual components of protein complexes. Threshold FC ≥ 2, p ≤ 0.05. IP3R is a site of xestospongin C action in females (orange line). b, von Frey testing in female mice ipsilateral (left panel) and contralateral (right panel) to IS MBP(84-104) (30 μg in 3 μl). At day 10 after IS MBP(84-104), IT administered IP3R inhibitor, xestospongin C (X2628, 1 nmol/5 µl, n = 5), but not vehicle 10% DMSO (5 µl, n = 4), attenuated the established allodynia. Control i.p. <t>gabapentin</t> (100 mg/kg, n = 3) also attenuated IS MBP(84-104) allodynia. The mean withdrawal tactile thresholds are in gram force (g) ± S.E.; two-way ANOVA (b, left: treatment × time f = 3.220, p = 0.0162, time f = 9.681, p = 0.0002, treatment f = 15.94, p = 0.0011, subject f = 1.125, p = 0.3797; b, right: treatment × time f = 1.407, p = 0.2482, time f = 1.346, p = 0.2803, treatment f = 0.2114, p = 0.8134, subject f = 3.109, p = 0.0107) with Dunnett's post hoc test: *, p ≤ 0.05; **, p ≤ 0.01; ****, p ≤ 0.0001 relative to the DMSO control. Not all groups were tested at the 15- and 45-min time points; these time points are shown in the graph, but were not included in the data analysis. Red arrows indicate drug administration.
Gabapentin, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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poly phenol metabolites sulfates and glucuronides  (Toronto Research Chemicals)
86
Toronto Research Chemicals poly phenol metabolites sulfates and glucuronides
IS MBP(84-104) causes striking sexual dimorphism in spinal nociceptive signaling. a, neuropathic pain network of PLC/IP3R/VGCC axis and ESR1/p300/CBP axis after IS MBP(84-104) in females (left panel) and males (right panel). Pathway components (molecules and complexes) are displayed as circles, arrows indicate molecular interactions according to Ingenuity IPA (Qiagen). Downstream biological processes are highlighted in blue. Red and green colors correspond to up- and down-regulated DE genes according to the color scale (log2FC). Gradient colors indicate regulation of individual components of protein complexes. Threshold FC ≥ 2, p ≤ 0.05. IP3R is a site of xestospongin C action in females (orange line). b, von Frey testing in female mice ipsilateral (left panel) and contralateral (right panel) to IS MBP(84-104) (30 μg in 3 μl). At day 10 after IS MBP(84-104), IT administered IP3R inhibitor, xestospongin C (X2628, 1 nmol/5 µl, n = 5), but not vehicle 10% DMSO (5 µl, n = 4), attenuated the established allodynia. Control i.p. <t>gabapentin</t> (100 mg/kg, n = 3) also attenuated IS MBP(84-104) allodynia. The mean withdrawal tactile thresholds are in gram force (g) ± S.E.; two-way ANOVA (b, left: treatment × time f = 3.220, p = 0.0162, time f = 9.681, p = 0.0002, treatment f = 15.94, p = 0.0011, subject f = 1.125, p = 0.3797; b, right: treatment × time f = 1.407, p = 0.2482, time f = 1.346, p = 0.2803, treatment f = 0.2114, p = 0.8134, subject f = 3.109, p = 0.0107) with Dunnett's post hoc test: *, p ≤ 0.05; **, p ≤ 0.01; ****, p ≤ 0.0001 relative to the DMSO control. Not all groups were tested at the 15- and 45-min time points; these time points are shown in the graph, but were not included in the data analysis. Red arrows indicate drug administration.
Poly Phenol Metabolites Sulfates And Glucuronides, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mitomycin c  (Selleck Chemicals)
96
Selleck Chemicals mitomycin c
IS MBP(84-104) causes striking sexual dimorphism in spinal nociceptive signaling. a, neuropathic pain network of PLC/IP3R/VGCC axis and ESR1/p300/CBP axis after IS MBP(84-104) in females (left panel) and males (right panel). Pathway components (molecules and complexes) are displayed as circles, arrows indicate molecular interactions according to Ingenuity IPA (Qiagen). Downstream biological processes are highlighted in blue. Red and green colors correspond to up- and down-regulated DE genes according to the color scale (log2FC). Gradient colors indicate regulation of individual components of protein complexes. Threshold FC ≥ 2, p ≤ 0.05. IP3R is a site of xestospongin C action in females (orange line). b, von Frey testing in female mice ipsilateral (left panel) and contralateral (right panel) to IS MBP(84-104) (30 μg in 3 μl). At day 10 after IS MBP(84-104), IT administered IP3R inhibitor, xestospongin C (X2628, 1 nmol/5 µl, n = 5), but not vehicle 10% DMSO (5 µl, n = 4), attenuated the established allodynia. Control i.p. <t>gabapentin</t> (100 mg/kg, n = 3) also attenuated IS MBP(84-104) allodynia. The mean withdrawal tactile thresholds are in gram force (g) ± S.E.; two-way ANOVA (b, left: treatment × time f = 3.220, p = 0.0162, time f = 9.681, p = 0.0002, treatment f = 15.94, p = 0.0011, subject f = 1.125, p = 0.3797; b, right: treatment × time f = 1.407, p = 0.2482, time f = 1.346, p = 0.2803, treatment f = 0.2114, p = 0.8134, subject f = 3.109, p = 0.0107) with Dunnett's post hoc test: *, p ≤ 0.05; **, p ≤ 0.01; ****, p ≤ 0.0001 relative to the DMSO control. Not all groups were tested at the 15- and 45-min time points; these time points are shown in the graph, but were not included in the data analysis. Red arrows indicate drug administration.
Mitomycin C, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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compound c  (Selleck Chemicals)
95
Selleck Chemicals compound c
IS MBP(84-104) causes striking sexual dimorphism in spinal nociceptive signaling. a, neuropathic pain network of PLC/IP3R/VGCC axis and ESR1/p300/CBP axis after IS MBP(84-104) in females (left panel) and males (right panel). Pathway components (molecules and complexes) are displayed as circles, arrows indicate molecular interactions according to Ingenuity IPA (Qiagen). Downstream biological processes are highlighted in blue. Red and green colors correspond to up- and down-regulated DE genes according to the color scale (log2FC). Gradient colors indicate regulation of individual components of protein complexes. Threshold FC ≥ 2, p ≤ 0.05. IP3R is a site of xestospongin C action in females (orange line). b, von Frey testing in female mice ipsilateral (left panel) and contralateral (right panel) to IS MBP(84-104) (30 μg in 3 μl). At day 10 after IS MBP(84-104), IT administered IP3R inhibitor, xestospongin C (X2628, 1 nmol/5 µl, n = 5), but not vehicle 10% DMSO (5 µl, n = 4), attenuated the established allodynia. Control i.p. <t>gabapentin</t> (100 mg/kg, n = 3) also attenuated IS MBP(84-104) allodynia. The mean withdrawal tactile thresholds are in gram force (g) ± S.E.; two-way ANOVA (b, left: treatment × time f = 3.220, p = 0.0162, time f = 9.681, p = 0.0002, treatment f = 15.94, p = 0.0011, subject f = 1.125, p = 0.3797; b, right: treatment × time f = 1.407, p = 0.2482, time f = 1.346, p = 0.2803, treatment f = 0.2114, p = 0.8134, subject f = 3.109, p = 0.0107) with Dunnett's post hoc test: *, p ≤ 0.05; **, p ≤ 0.01; ****, p ≤ 0.0001 relative to the DMSO control. Not all groups were tested at the 15- and 45-min time points; these time points are shown in the graph, but were not included in the data analysis. Red arrows indicate drug administration.
Compound C, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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doxorubicin hydrochloride  (Toronto Research Chemicals)
93
Toronto Research Chemicals doxorubicin hydrochloride
IS MBP(84-104) causes striking sexual dimorphism in spinal nociceptive signaling. a, neuropathic pain network of PLC/IP3R/VGCC axis and ESR1/p300/CBP axis after IS MBP(84-104) in females (left panel) and males (right panel). Pathway components (molecules and complexes) are displayed as circles, arrows indicate molecular interactions according to Ingenuity IPA (Qiagen). Downstream biological processes are highlighted in blue. Red and green colors correspond to up- and down-regulated DE genes according to the color scale (log2FC). Gradient colors indicate regulation of individual components of protein complexes. Threshold FC ≥ 2, p ≤ 0.05. IP3R is a site of xestospongin C action in females (orange line). b, von Frey testing in female mice ipsilateral (left panel) and contralateral (right panel) to IS MBP(84-104) (30 μg in 3 μl). At day 10 after IS MBP(84-104), IT administered IP3R inhibitor, xestospongin C (X2628, 1 nmol/5 µl, n = 5), but not vehicle 10% DMSO (5 µl, n = 4), attenuated the established allodynia. Control i.p. <t>gabapentin</t> (100 mg/kg, n = 3) also attenuated IS MBP(84-104) allodynia. The mean withdrawal tactile thresholds are in gram force (g) ± S.E.; two-way ANOVA (b, left: treatment × time f = 3.220, p = 0.0162, time f = 9.681, p = 0.0002, treatment f = 15.94, p = 0.0011, subject f = 1.125, p = 0.3797; b, right: treatment × time f = 1.407, p = 0.2482, time f = 1.346, p = 0.2803, treatment f = 0.2114, p = 0.8134, subject f = 3.109, p = 0.0107) with Dunnett's post hoc test: *, p ≤ 0.05; **, p ≤ 0.01; ****, p ≤ 0.0001 relative to the DMSO control. Not all groups were tested at the 15- and 45-min time points; these time points are shown in the graph, but were not included in the data analysis. Red arrows indicate drug administration.
Doxorubicin Hydrochloride, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ivermectin d 2  (Toronto Research Chemicals)
93
Toronto Research Chemicals ivermectin d 2
IS MBP(84-104) causes striking sexual dimorphism in spinal nociceptive signaling. a, neuropathic pain network of PLC/IP3R/VGCC axis and ESR1/p300/CBP axis after IS MBP(84-104) in females (left panel) and males (right panel). Pathway components (molecules and complexes) are displayed as circles, arrows indicate molecular interactions according to Ingenuity IPA (Qiagen). Downstream biological processes are highlighted in blue. Red and green colors correspond to up- and down-regulated DE genes according to the color scale (log2FC). Gradient colors indicate regulation of individual components of protein complexes. Threshold FC ≥ 2, p ≤ 0.05. IP3R is a site of xestospongin C action in females (orange line). b, von Frey testing in female mice ipsilateral (left panel) and contralateral (right panel) to IS MBP(84-104) (30 μg in 3 μl). At day 10 after IS MBP(84-104), IT administered IP3R inhibitor, xestospongin C (X2628, 1 nmol/5 µl, n = 5), but not vehicle 10% DMSO (5 µl, n = 4), attenuated the established allodynia. Control i.p. <t>gabapentin</t> (100 mg/kg, n = 3) also attenuated IS MBP(84-104) allodynia. The mean withdrawal tactile thresholds are in gram force (g) ± S.E.; two-way ANOVA (b, left: treatment × time f = 3.220, p = 0.0162, time f = 9.681, p = 0.0002, treatment f = 15.94, p = 0.0011, subject f = 1.125, p = 0.3797; b, right: treatment × time f = 1.407, p = 0.2482, time f = 1.346, p = 0.2803, treatment f = 0.2114, p = 0.8134, subject f = 3.109, p = 0.0107) with Dunnett's post hoc test: *, p ≤ 0.05; **, p ≤ 0.01; ****, p ≤ 0.0001 relative to the DMSO control. Not all groups were tested at the 15- and 45-min time points; these time points are shown in the graph, but were not included in the data analysis. Red arrows indicate drug administration.
Ivermectin D 2, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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clopidogrel hydrogen sulfate  (Toronto Research Chemicals)
93
Toronto Research Chemicals clopidogrel hydrogen sulfate
IS MBP(84-104) causes striking sexual dimorphism in spinal nociceptive signaling. a, neuropathic pain network of PLC/IP3R/VGCC axis and ESR1/p300/CBP axis after IS MBP(84-104) in females (left panel) and males (right panel). Pathway components (molecules and complexes) are displayed as circles, arrows indicate molecular interactions according to Ingenuity IPA (Qiagen). Downstream biological processes are highlighted in blue. Red and green colors correspond to up- and down-regulated DE genes according to the color scale (log2FC). Gradient colors indicate regulation of individual components of protein complexes. Threshold FC ≥ 2, p ≤ 0.05. IP3R is a site of xestospongin C action in females (orange line). b, von Frey testing in female mice ipsilateral (left panel) and contralateral (right panel) to IS MBP(84-104) (30 μg in 3 μl). At day 10 after IS MBP(84-104), IT administered IP3R inhibitor, xestospongin C (X2628, 1 nmol/5 µl, n = 5), but not vehicle 10% DMSO (5 µl, n = 4), attenuated the established allodynia. Control i.p. <t>gabapentin</t> (100 mg/kg, n = 3) also attenuated IS MBP(84-104) allodynia. The mean withdrawal tactile thresholds are in gram force (g) ± S.E.; two-way ANOVA (b, left: treatment × time f = 3.220, p = 0.0162, time f = 9.681, p = 0.0002, treatment f = 15.94, p = 0.0011, subject f = 1.125, p = 0.3797; b, right: treatment × time f = 1.407, p = 0.2482, time f = 1.346, p = 0.2803, treatment f = 0.2114, p = 0.8134, subject f = 3.109, p = 0.0107) with Dunnett's post hoc test: *, p ≤ 0.05; **, p ≤ 0.01; ****, p ≤ 0.0001 relative to the DMSO control. Not all groups were tested at the 15- and 45-min time points; these time points are shown in the graph, but were not included in the data analysis. Red arrows indicate drug administration.
Clopidogrel Hydrogen Sulfate, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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vitamin c  (Selleck Chemicals)
94
Selleck Chemicals vitamin c
IS MBP(84-104) causes striking sexual dimorphism in spinal nociceptive signaling. a, neuropathic pain network of PLC/IP3R/VGCC axis and ESR1/p300/CBP axis after IS MBP(84-104) in females (left panel) and males (right panel). Pathway components (molecules and complexes) are displayed as circles, arrows indicate molecular interactions according to Ingenuity IPA (Qiagen). Downstream biological processes are highlighted in blue. Red and green colors correspond to up- and down-regulated DE genes according to the color scale (log2FC). Gradient colors indicate regulation of individual components of protein complexes. Threshold FC ≥ 2, p ≤ 0.05. IP3R is a site of xestospongin C action in females (orange line). b, von Frey testing in female mice ipsilateral (left panel) and contralateral (right panel) to IS MBP(84-104) (30 μg in 3 μl). At day 10 after IS MBP(84-104), IT administered IP3R inhibitor, xestospongin C (X2628, 1 nmol/5 µl, n = 5), but not vehicle 10% DMSO (5 µl, n = 4), attenuated the established allodynia. Control i.p. <t>gabapentin</t> (100 mg/kg, n = 3) also attenuated IS MBP(84-104) allodynia. The mean withdrawal tactile thresholds are in gram force (g) ± S.E.; two-way ANOVA (b, left: treatment × time f = 3.220, p = 0.0162, time f = 9.681, p = 0.0002, treatment f = 15.94, p = 0.0011, subject f = 1.125, p = 0.3797; b, right: treatment × time f = 1.407, p = 0.2482, time f = 1.346, p = 0.2803, treatment f = 0.2114, p = 0.8134, subject f = 3.109, p = 0.0107) with Dunnett's post hoc test: *, p ≤ 0.05; **, p ≤ 0.01; ****, p ≤ 0.0001 relative to the DMSO control. Not all groups were tested at the 15- and 45-min time points; these time points are shown in the graph, but were not included in the data analysis. Red arrows indicate drug administration.
Vitamin C, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


IS MBP(84-104) causes striking sexual dimorphism in spinal nociceptive signaling. a, neuropathic pain network of PLC/IP3R/VGCC axis and ESR1/p300/CBP axis after IS MBP(84-104) in females (left panel) and males (right panel). Pathway components (molecules and complexes) are displayed as circles, arrows indicate molecular interactions according to Ingenuity IPA (Qiagen). Downstream biological processes are highlighted in blue. Red and green colors correspond to up- and down-regulated DE genes according to the color scale (log2FC). Gradient colors indicate regulation of individual components of protein complexes. Threshold FC ≥ 2, p ≤ 0.05. IP3R is a site of xestospongin C action in females (orange line). b, von Frey testing in female mice ipsilateral (left panel) and contralateral (right panel) to IS MBP(84-104) (30 μg in 3 μl). At day 10 after IS MBP(84-104), IT administered IP3R inhibitor, xestospongin C (X2628, 1 nmol/5 µl, n = 5), but not vehicle 10% DMSO (5 µl, n = 4), attenuated the established allodynia. Control i.p. gabapentin (100 mg/kg, n = 3) also attenuated IS MBP(84-104) allodynia. The mean withdrawal tactile thresholds are in gram force (g) ± S.E.; two-way ANOVA (b, left: treatment × time f = 3.220, p = 0.0162, time f = 9.681, p = 0.0002, treatment f = 15.94, p = 0.0011, subject f = 1.125, p = 0.3797; b, right: treatment × time f = 1.407, p = 0.2482, time f = 1.346, p = 0.2803, treatment f = 0.2114, p = 0.8134, subject f = 3.109, p = 0.0107) with Dunnett's post hoc test: *, p ≤ 0.05; **, p ≤ 0.01; ****, p ≤ 0.0001 relative to the DMSO control. Not all groups were tested at the 15- and 45-min time points; these time points are shown in the graph, but were not included in the data analysis. Red arrows indicate drug administration.

Journal: The Journal of Biological Chemistry

Article Title: A myelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice

doi: 10.1074/jbc.RA120.013696

Figure Lengend Snippet: IS MBP(84-104) causes striking sexual dimorphism in spinal nociceptive signaling. a, neuropathic pain network of PLC/IP3R/VGCC axis and ESR1/p300/CBP axis after IS MBP(84-104) in females (left panel) and males (right panel). Pathway components (molecules and complexes) are displayed as circles, arrows indicate molecular interactions according to Ingenuity IPA (Qiagen). Downstream biological processes are highlighted in blue. Red and green colors correspond to up- and down-regulated DE genes according to the color scale (log2FC). Gradient colors indicate regulation of individual components of protein complexes. Threshold FC ≥ 2, p ≤ 0.05. IP3R is a site of xestospongin C action in females (orange line). b, von Frey testing in female mice ipsilateral (left panel) and contralateral (right panel) to IS MBP(84-104) (30 μg in 3 μl). At day 10 after IS MBP(84-104), IT administered IP3R inhibitor, xestospongin C (X2628, 1 nmol/5 µl, n = 5), but not vehicle 10% DMSO (5 µl, n = 4), attenuated the established allodynia. Control i.p. gabapentin (100 mg/kg, n = 3) also attenuated IS MBP(84-104) allodynia. The mean withdrawal tactile thresholds are in gram force (g) ± S.E.; two-way ANOVA (b, left: treatment × time f = 3.220, p = 0.0162, time f = 9.681, p = 0.0002, treatment f = 15.94, p = 0.0011, subject f = 1.125, p = 0.3797; b, right: treatment × time f = 1.407, p = 0.2482, time f = 1.346, p = 0.2803, treatment f = 0.2114, p = 0.8134, subject f = 3.109, p = 0.0107) with Dunnett's post hoc test: *, p ≤ 0.05; **, p ≤ 0.01; ****, p ≤ 0.0001 relative to the DMSO control. Not all groups were tested at the 15- and 45-min time points; these time points are shown in the graph, but were not included in the data analysis. Red arrows indicate drug administration.

Article Snippet: Gabapentin was from Toronto Research Chemicals (Ontario, Canada), and xestospongin C (X2628) was from Sigma-Aldrich.

Techniques: Control